By Alan De Mause

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For 83% the more of human versus of species with more of chimp but the increasingly longer primate with non-primate (1989) found a similar pattern distantly related bovids; rapidly evolving D-loop this region of these For strains of Drosophila melanogaster, transitions accounted of changes in silent codon positions (4 protein coding genes); for distantly related pair Drosophila melanogaster and Drosophila yakuba, transitions accounted for only 18% of such changes (6 protein coding genes) (Wolstenholme and Clary 1985).

As in nuclear non-coding regions (introns, spacer regions, pseudogenes) this lack of coding suggests a lack of functional constraints and would explain the hypervariabi1ity (Li et a1. 1984, Hillis and Davis 1986). This level of variability has made the control region useful for studies of relationships below the species level (Cann et a1. 1987, Thomas et a1. 1990). In lower vertebrates and invertebrates, the control region is sometimes characterized by extreme length variability (Moritz et a1. Harrison 1989, Boyce et a1.

Levinson, G. L. T. A. Gutman 1985 Cross-hybridizing snake satellite, Drosophila, and mouse DNA sequences may have arisen independently. Mol. BioI Evol. 2: 494-504. Miyashita, N. H. Langley 1988 Molecular and phenotypic variation of the white locus region in Drosophila melanogaster. Genetics 120: 199~212. c. R. Cox 1989 Mutation detection by PCR, GCclamps, and denaturing gradient gel electrophoresis. A. Erlich, Editor. Y. Nei, M. and P. Tajima 1981 DNA polymorphism detectable by restriction endonucleases.

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